Dialogue of Life entails the social interaction in daily activities in spite of acknowledging the differences that exist. The writer adopts the use of synthetic and interpretative approaches in the discussion. This paper gives an overview of how religiously pluralistic the Ghanaian society is. It gives a brief historical background to the three main religions in Ghana and discusses Dialogue of Life in general after a brief definition. It deals with the phenomenon of Dialogue of Life in Ghanaian schools and some challenges associated to it. It continues to discuss the significance of Dialogue of Life. The paper also makes a case for the use of Dialogue of Life in Ghanaian schools to maintain peace and tolerance among the adherents of the various religions in Ghana.