The role of the Technical and Vocational Education and Training (TVET) in achieving Ghana’s industrialization drive after 60 years of independence cannot be over emphasized. Despite many successes and gains chalked in attaining this, there are more constraints that bedeviled these successes. TVET has played lots of active roles in realizing this goal through the evolution of skilled level manpower for the attainment of industrialization. The objectives of this paper were to study the role of TVET in Ghana’s industrialization drive after many years of independence, find the constraints of TVET and identify the management structures of TVET institutions in Ghana. The findings of this paper are that TVET education is widely patronized by the youth and has helped reduce the high level of widespread poverty, crime and deprivation, self-reliance, entrepreneurship, job creation among others because the skill learned is practiced on farmlands, in the mines, in the forest, at the workshop and at dressmaking etc.