The paper examines the effect of Supply Chain Management Practices (SCMPs) on Performance of Small and Medium Enterprises (SMEs) within the Sekondi-Takoradi Metropolis in Ghana. Registered SMESs with National Board for Small Scale Industries who have operated for at least three years were used. The study adopted a model used by Li et al (2005). The data was analyzed using the Pearson correlation matrix. Self-administered questionnaires were used to collect data for the study.