The study sought to examine the quality of teaching and learning in vocational schools and its effect on graduates skill acquisition and job placement. Purposive sampling technique was employed to select a total of 130 respondents comprising 96 students, 24 past students, 7 teachers and 3 head teachers from the vocational institutes in the central and western regions of Ghana. Instruments for data collection were questionnaire, interview guide and observation guide. Episodic interview was also used whenever necessary. Findings were given qualitative interpretations with support of percentages and numbers.