The purpose of the study was to examine how special education teachers use assistive technology in educating persons with special needs in some selected schools in the Northern Region of Ghana. A sample of 55 teachers was selected from the five special schools/institutions for the data gathering of the study. The instrument used to collect the data was structured questionnaire. The data was presented using tables and analysed by calculating the standard deviations and the mean of the responses. The findings revealed that, teachers agreed that the use of assistive technology is very effective in teaching persons with special needs. It was also proven that teachers encountered a lot of challenges in using assistive technology.