The main purpose of this study was to examine the knowledge and awareness level of drivers and commuters regarding the usage of seat belt as a safety restraint mechanism in Ghana, using Tamale Metropolis as a case study. The study employed quantitative research approach and descriptive research design. The target population for this study comprises commuters from Tamale to Bolgatanga; from the central business district to education ridge; and licensed drivers for both private and commercial vehicles in the Tamale Metropolis. A well-structured questionnaire was used to collect data from three hundred (300) respondents through a simple random sampling technique. The data collected was analyzed using the Statistical Package for Social Scientists (SPSS). The study found that most respondents had adequate knowledge regarding the importance of the use of seat belts to both the driver and commuters. The study confirmed that, the use of seat belt can greatly increase the drivers’ ability to maintain control of vehicle during a crash.