Ethnoviolence refers to antagonistic conduct toward other person(s) or group(s) on the basis of prejudgment. Psychosocial programming explains the fact that neurochemical processes and social factors, taken together, precondition members of the society to behave in patterns which are sometimes antithetical to social order. Such behavioural tendencies are perpetuated until a point in time when the status quo is adequately interrupted by relevant social dynamics and new behavioural dispositions are induced. Despite concerted effort by the global community to reduce the spate of ethnoviolence, documented evidence shows that prejudice – related crime is on the increase. The study sought to explore possible psychosocial programming and related undercurrents as precursors of various forms of ethnoviolence, and also to develop a conceptual framework for the subject matter of psychosocial programming. Exploratory approach was adopted to examine the interconnectivity between relevant neurochemical processes, social interactions, and various forms of intercommunication, as well as how the interplay of these psychosocial processes influences social attitudes and society at large.