To ascertain whether tillage land forms and orientation of cassava stem cuttings at planting affect yield, a factorial experiment comprising three landforms and three stem orientations were tested in 2010 and 2012 at Wenchi. The land forms were: (i) no till, (ii) mounds and (iii) ridges, while stem orientations comprised: (a) vertical, (b) horizontal and (c) inclined. The nine treatment combinations were replicated four times in a randomized complete block design (RCBD), and the test crop was the variety, Tekbankye. No till yielded a mean of 17.96 tonnes/ha in tuberous roots, while mounds gave 21.21 tonnes/ha and ridges yielded 23.35 tonnes/ha. Vertical cuttings averaged 21.06 tonnes/ha, horizontal ones gave 21.22 tonnes/ha and those inclined yielded 20.25 tonnes/ha.