The objective of this paper is to contribute to the debate on the role of the Tamale Central Prisons towards reforming inmates in the Northern Region of Ghana. A cross sectional design was used and triangulated with some qualitative data. One hundred and fifty prison inmates were randomly selected and both quantitative and qualitative data were gathered with instruments such as questionnaire, interview guide and observation. Data gathered were analyzed with the aid of the Statistical Product for Service Solution and descriptive statistics such as cross tabulation, frequencies and percentages were used to present the findings. The study disclosed that formal education, skill development training, information communication technology education among others were the main efforts directed at reforming inmates in the Tamale Central Prisons.